1132 Medical Laboratories
Our primary research interest concerns neoplasms of the mature B cell and plasma cell lineage, such as multiple myeloma, Waldenström macroglobulinemia and Burkitt lymphoma. Relying in part on gene-insertion mice that mimic the human MYC-activating t(8;14)(q24;q32) translocation, we recapitulate important features of these neoplasms in single and compound transgenic mice. We then take advantage of mouse models of this sort to elucidate mechanisms of neoplastic B cell and plasma cell development and evaluate new approaches to cancer treatment and prevention. The long-term goal of our work is to improve the outcome of patients with myeloma, lymphoma and other blood cancers. To that end, our laboratory maintains close ties with The University of Iowa Holden Comprehensive Cancer Center and the Interdisciplinary Graduate Program in Immunology at the Carver College of Medicine.
Left to right: Siggy Janz, Krista Lingle Mullen, Xuefang Jing, Michael Pisano